I don’t often “recommend” software but there are two critical bits of software that everyone needs a good anti virus and good backup.
GFI Backup for Windows handles traditional folder and files backups, but it also has special options for backing up your registry, email, and program settings (including setting for programs like Skype, Putty, Photoshop, Dreamweaver, Winamp, Firefox, IE and Opera).
Backups can be saved to CD/DVD, removable drives, LAN folders, or remote FTP. Scheduling, compression, and AES encryption are also supported. For those who use an external hard drive or a NAS, GFI can also handle synchronization tasks.